Poster E11, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Localizing six bilateral sensory-biased regions in human frontal cortex.
Abigail Noyce1, Sean Tobyne1, Samantha Michalka2, Barbara Shinn-Cunningham1, David Somers1; 1Boston University, 2Olin College of Engineering
Previously, we identified four bilateral sensory-biased structures in human caudolateral frontal cortex (LFC; Michalka et al. 2015, Noyce et al. 2017). Visual-biased regions in superior and inferior precentral sulcus are interdigitated with auditory-biased regions in transverse gyrus bridging precentral sulcus and caudal inferior frontal sulcus. An analysis of functional connectivity between posterior sensory cortex and LFC suggested additional candidate sensory-biased regions extending rostrally along the inferior frontal sulcus and frontal operculum (Tobyne et al. 2017). Here, we collected fMRI while participants performed visual and auditory 2-back working memory (stimuli were face photographs and animal vocalizations, respectively). A direct contrast of visual and auditory working memory conditions within each individual subject confirmed an additional bilateral visual-biased region in middle inferior frontal sulcus and an additional bilateral auditory-biased region in frontal operculum. We hypothesize that multiple regions sharing a sensory bias are specialized for different cognitive computations. To test this, we measured fMRI activation (against passive sensorimotor control) in working memory and selective attention tasks. Using resting-state functional connectivity, we will also examine communication among sensory-biased LFC regions and posterior sensory cortex to further differentiate their functionality. Mapping sensory modality-specific preferences in human LFC has potential to effectively parcellate and characterize large portions of human frontal cortex.
Topic Area: ATTENTION: Multisensory