Poster F88, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Structural and Functional Correlates of Musical Anhedonia
Sean Patterson1, Monday Zhou1, Psyche Loui1; 1Wesleyan University
Musical Anhedonia is a condition characterized by a specific lack of reward responses to music, despite normal hedonic responses to other rewarding stimuli. Here we test the hypothesis that musical anhedonia is linked to abnormal structural and/or functional connectivity between auditory regions, specifically the superior temporal gyrus, and reward-sensitive regions such as the nucleus accumbens and anterior insula. We present behavioral, DTI, and rsfMRI results on a subject presenting with this deficiency, BW, compared to 46 neurotypical adults. BW showed extremely anhedonic responses (>5SD from mean) to sound items on the Physical Anhedonia Scale, but was normal in all other hedonic categories. In DTI tractography, BW showed increased FA and lower volume in the tracts between both the left and right auditory cortices and the nucleus accumbens and anterior insula, suggesting that different patterns in white matter pathways between auditory and reward regions could underlie these behavioral differences. Furthermore, rsfMRI was used to compare functional connectivity within and between auditory and reward regions for BW and controls. Results show less functional connectivity between the left and right auditory cortices in BW as compared to controls, further suggesting differences in auditory access to the reward system in musical anhedonics. Together, results suggest that musical anhedonia is associated with both structural and functional differences in connectivity between the auditory and reward systems.
Topic Area: PERCEPTION & ACTION: Audition