Poster C33, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Altered Functional Networks Underlying Post-Error Adaptation in Women with Drug Use Disorder and Comorbid Post-Traumatic Stress Disorder
Bradford S. Martins1, Clinton D. Kilts1, G. Andrew James1; 1University of Arkansas for Medical Sciences
Individuals with either Drug Use Disorder (DUD) or Post-Traumatic Stress Disorder (PTSD) have well-established deficits in error processing, yet no research has studied the neural correlates of these processes in comorbidity. We conducted a retrospective analysis of women with DUD, DUD+PTSD, and healthy comparison subjects to model altered interactions among neural regions underlying error-adaptation with comorbidity. We hypothesized that altered connectivity in the salience and reward networks would most significantly contribute to post-error adaptation, and that differences in these two networks would be seen across disorder groups. 44 females (healthy controls=23, cocaine use disorder=11, comorbid=11) underwent fMRI neuroimaging while performing a Stop Signal task. Dynamic causal modeling using Bayesian statistics characterized network connectivity differences between 32 regions in 5 networks across the 3 subgroups. Pearson’s correlation coefficient was used to relate altered connections to post-error adaptation (measured by post-error slowing on subsequent Go trials). One connection in the comorbid group and one connection in the DUD group were significantly modulated by post-error adaptation. Group differences in the neural correlates underlying post-error adaptation showed that while both groups share altered network connectivity involved in error recognition and error adaptation, error adaptation in comorbid females is more closely associated with altered connectivity involving regions that confer cognitive-flexibility and learning, while error adaptation in DUD females is more closely related to altered connectivity involved in attention and self-control. By highlighting the unique neural differences underlying similar behaviors across disorder groups, we can develop better treatment strategies for individuals with comorbid diagnoses.
Topic Area: EXECUTIVE PROCESSES: Monitoring & inhibitory control