Poster C4, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Working memory recruitment and network membership of visual, auditory and tactile sensory-biased regions in lateral frontal cortex
Sean M. Tobyne1, Abigail L. Noyce1, James A. Brissenden1, Stephanie R. Jones2, Manuel Gomez-Ramirez2, Christopher I. Moore2, David C. Somers1; 1Boston University, 2Brown University
Our laboratory and others have recently reported that preferences for sensory modality characterize distinct subregions of lateral frontal cortex (LFC). We previously used an auditory/visual sustained attention fMRI task to identify four bilateral interleaved regions in LFC with a bias for attention to visual or auditory stimuli (Michalka et al., Neuron, 2015); and have since replicated this finding with an auditory/visual working memory paradigm (Noyce et al., JNeurosci, 2017). These regions form intrinsic networks with posterior sensory-biased regions; a finding we replicated using data from the Human Connectome Project (Tobyne et al., Neuroimage, 2017). Here, we extend our auditory/visual fMRI paradigms to include tactile stimulation. While prior unimodal tactile studies have reported LFC recruitment, visual-, auditory- and tactile-biased cognitive regions within individual subjects remains to be investigated in concert. We observe two unique tactile-biased regions of LFC that abut previously identified auditory- and visual-biased regions. The whole-brain intrinsic connectivity profiles of these six bilateral LFC regions reveal that LFC ROIs possess unique fingerprints of network membership both across and within a modality. Our results elucidate the complex topography of LFC and highlight the specific profiles of connectivity and task recruitment between and across modality-biased LFC ROIs. In ongoing studies, we are analyzing whether these same representations can be isolated with MEG. Together, these results shed light on the complexity of LFC modality-biased network nodes supporting higher-order cognition.
Topic Area: ATTENTION: Multisensory