Poster C85, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
The role of physical fitness components on overall and regional cortical thickness in overweight/obese children: preliminary results from the ActiveBrains Project
Irene Esteban-Cornejo1,2, Jose Mora-González1, Cristina Cadenas-Sánchez1, Oren Contreras-Rodriguez3,4, Juan Verdejo-Roman5, Pontus Henriksson1,6, Jairo Migueles1, Maria Rodriguez-Ayllon1, Pablo Molina-García1, Charles Hillman2, Andrés Catena5, Francisco B. Ortega1; 1PROFITH “PROmoting FITness and Health through physical activity” research group, University of Granada, Granada, Spain, 2Northeastern University, Boston, MA, 3Bellvitge Biomedical Research Institute-IDIBELL, Barcelona, Spain., 4Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Barcelona, Spain., 5Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain., 6Karolinska Institutet, Huddinge, Sweden.
Aim: To examine the associations of physical fitness components (i.e. cardiorespiratory fitness, speed-agility and muscular fitness) with overall and regional cortical thickness in overweight/obese children. Methods: A total of 101 overweight/obese children aged 8-11 years were recruited from Granada, Spain. The physical fitness components were assessed following the ALPHA health-related fitness test battery. T1-weighted images were acquired with a 3.0 Tesla Siemens Magnetom Tim Trio system. Overall and regional cortical thickness was computed with FreeSurfer software (v 5.3). For overall cortical thickness, averages cortical thickness across the entire brain were calculated. For regional cortical thickness, we focused on specific frontal (i.e. right premotor cortex, right supplementary motor cortex and left inferior frontal gyrus), temporal (i.e. left inferior temporal gyrus and right parahippocampal gyrus) and occipital (i.e. right calcarine cortex) regions, as we have previously found that physical fitness was associated with greater cortical volume in these specific areas. All analyses were controlled for sex, peak high velocity offset, and parental education. Results: Cardiorespiratory fitness and speed-agility, but not muscular fitness, were related to overall cortical thickness (Beta's = 0.314 and 0.301, respectively; both P < 0.01). Only speed-agility was related to superior temporal cortical thickness (Beta = 0.294; P=0.01). No other associations were found between the physical fitness components and specific regional cortical thickness. Conclusion: These findings suggest that cardiorespiratory fitness and speed-agility might positively influence development of overall cortical thickness to counteract the potentially detrimental effect of excess adiposity on brain structure during childhood.
Topic Area: NEUROANATOMY