Poster C89, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Abnormal resting-state EEG cross-frequency coupling in patients with tinnitus
Byoung-Kyong Min1, Min-Hee Ahn1, Sung Kwang Hong1,2; 1Korea University, 2Hallym University College of Medicine
Tinnitus is the psychoacoustic phantom awareness of internally generated sound in the absence of external sound. We recently reported neurophysiological evidence for deficits in both bottom-up and top-down processing in patients with tinnitus. However, it is still uncertain whether tinnitus symptoms are also reflected in the resting-state brain. In the present study, we analyzed phase-amplitude cross-frequency coupling (CFC) to evaluate resting-state electroencephalographic (EEG) data in healthy participants and patients with tinnitus. Healthy participants exhibited robust frontal delta-phase/central high-gamma-amplitude CFC that was significantly absent in patients with tinnitus (p < 0.001). Since low-frequency phase and high-frequency amplitude coupling reflects large-scale communication during cognitive processing, the absence of frontal delta-phase/central high-gamma-amplitude CFC in patients with tinnitus may reflect deficient integration over inter-regional functional brain networks (particularly, impaired frontal top-down inhibitory control) in the resting state. Our observations are indicative of abnormal reorganization or maladaptive neuroplasticity in the auditory default mode network in tinnitus.
Topic Area: PERCEPTION & ACTION: Audition