Poster D48, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
fMRI Mapping of Language Areas in Bilingual Neurosurgical Patients
Lok Wa Laura Leung1,2, Prashin Unadkat1, Luca Fumagalli1,3, Laura Rigolo1, Alexandra Golby1, Yanmei Tie1; 1Harvard Medical School, Boston, MA, USA, 2The Chinese University of Hong Kong, Hong Kong, 3Università degli Studi di Milano-Bicocca, Milan, Italy
An important issue of neurosurgical preoperative planning is the ability to achieve maximal resection whilst minimizing the risk of severe post-operative neurological impairment. Previous literature has suggested post-operative disparity in language ability of bilingual brain tumor patients. In this study, active cortical areas were mapped using functional MRI (fMRI) for bilingual neurosurgical patients in an attempt to localize language areas. Fifteen bilingual patients (range 23 to 59 years) with epilepsy and brain tumors participated in the study through consent with the Institutional Review Board (IRB). Subjects performed the antonym generation task in English and one non-English language. Acquisition of images was achieved using 3T scanners. Blood-oxygen-level dependent (BOLD) fMRI data were analyzed using Statistical Parametric Mapping software (SPM12). Task-induced activations were analyzed focusing on structurally-defined language regions of interests (ROIs) including Broca’s and Wernicke’s areas. Activation volume, laterality index (LI) and DICE coefficient (percentage overlap) were subsequently calculated. Our results revealed no significant differences between the two languages’ fMRI results (English vs. non-English): (1) Activation volume: Broca’s area: 8080.191 +/-3936.811mm vs 8732.119 +/-4293.954mm, Wernicke’s area: 2081.375 +/-1401.422mm vs 2782.245 +/-2474.413mm; (2) LI: 0.542 +/-0.269 vs 0.559 +/-0.284. The DICE coefficient exhibited fair overlap (0.520 +/-0.171). Although results indicated similar activation extent and lateralization for both languages in bilingual patients, our result suggested that dual mapping could improve the sensitivity of pre-operative planning which is of great importance for surgical planning. Further studies with larger groups of bilingual patients are needed to support our conclusions.
Topic Area: LANGUAGE: Other