Poster E116, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Reliability of the Mismatch Negativity in a Kindergarten Population Oversampled for Dyslexia Risk
Sean McWeeny1, Brittany Manning1, Emily M. Harriott1, Sarah D. Beach2,3, Ola Ozernov-Palchik4, John D. E. Gabrieli2, Nadine Gaab3, Elizabeth S. Norton1; 1Northwestern University, 2Massachusetts Institute of Technology, 3Harvard University, 4Tufts University
Developmental dyslexia cannot currently be diagnosed until a child has failed to learn to read as expected. Researchers have sought to find neural measures that may help predict a child’s later reading ability. One of these measures is the mismatch negativity (MMN), an event-related potential (ERP) component elicited by an oddball within a stream of standard stimuli. The MMN is thought to reflect automatic auditory change detection, and has been shown to predict later reading. For the MMN to be clinically useful, its psychometric properties must be further evaluated. In a sample of 130 kindergarten children oversampled for risk for dyslexia, we calculated reliability measures for early and late MMN time windows in terms of different electrodes of interest, stimuli, and response mean amplitude. Subjects were presented with 2 blocks of 1200 trials; one using /ba/ as the standard and one using /da/ as the standard. Cronbach’s alpha across 9 different fronto-central electrode sites was excellent (α > .90) for both early and late MMN mean amplitude. Group level comparisons between /da/ and /ba/ were non-significant, indicating that on average, there is no difference between the stimuli; t(129) = .26, p = .79. However, reliability of an individual’s early and late MMN amplitude is not as reliable (r=.16) as previous research has shown. This may affect the strength of the conclusions we can draw from models incorporating these predictors. We discuss future directions for using this component as a predictor of future reading abilities.
Topic Area: METHODS: Electrophysiology