Poster D67, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network
Andrew McKinnon1,4,8, Ian Hickie1, Jan Scott1, Shantel Duffy1,7, Louisa Norrie1, Zoe Terpening1, Ron Grunstein5, Jim Lagopoulos1,6, Jennifer Batchelor4, Simon Lewis1, James Shine1, Sharon Naismith1,2,3; 1Healthy Brain Ageing Program, 2School of Psychology, 3Charles Perkins Centre and Brain and Mind Centre, The University of Sydney, 4Department of Psychology, Macquarie University, 5Woolcock Institute of Medical Research, NSW, Australia, 6Sunshine Coast Mind and Neuroscience - Thompson Institute, University of the Sunshine Coast, QLD, Australia, 7Central Clinical School, Faculty of Medicine, The University of Sydney, 8Cognition and Neuroimaging Lab, Department of Psychology, The University of Arizona
The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted). 52 of those with a lifetime history of depression also met criteria for Mild Cognitive Impairment (MCI). Participants underwent resting-state fMRI along with comprehensive psychiatric, neuropsychological, and medical assessment. Subjective sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI). Sleep disturbance was defined as a PSQI score>5. A total of 68% (n=48) of cases with a lifetime history of depression met criteria for sleep-disturbance. Relative to controls, those with lifetime major depression demonstrated significantly increased functional connectivity between the ventromedial prefrontal cortex and the temporal pole. Within the depression group (n = 48), those with current sleep disturbance had significantly increased connectivity between the anterior medial prefrontal cortex and both the parahippocampal cortex and the hippocampal formation, relative to those without sleep disturbance (n = 23). These results were present after controlling for MCI diagnosis. Current sleep disturbance together with depression is associated with distinct abnormalities in DMN functioning incorporating regions responsible for self-reflection and declarative memory processes. Impaired sleep is associated with increased connectivity between these regions.
Topic Area: LONG-TERM MEMORY: Episodic