Poster B84, Sunday, March 25, 8:00-10:00 am, Exhibit Hall C
Evidence of Non-reciprocal Topological Connections between Frontal Association Cortex and Temporal Cortex in the Rat
Stacey Bedwell1, Chris Tinsley2; 1Birmingham City University, 2Nottingham Trent University
The prefrontal cortex (PFC) is known to be important in a wide range of high order and complex cognitive processes. The most frontal aspect, Frontal association cortex (FrA) remains to be a relatively little understood cortical region, both in terms of function and underlying anatomical structure. We investigated the anatomical organisation of connections from FrA to regions of temporal cortex in the rat. Retrograde (Fluoro-Gold) and anterograde (Fluoro-Ruby) neuroanatomical tracers were injected into equally spaced regions of FrA and the locations of their projections to temporal cortex (PRh, Ent) studied in three axes of orientation. Statistical analyses revealed significant evidence of topological ordering in the dorsal-ventral, anterior-posterior and medial- lateral axes (p<.001). Labelled afferent and efferent connections showed evidence of similar patterns of ordering, however were not found in the same columnar regions of temporal cortex. Little evidence of reciprocal connectivity i.e. inputs and outputs occurring in the same region was found in the FrA – temporal cortex pathway. Taken with previous observations of prefrontal cortex structural organisation, the findings presented here provide evidence to support a gradient of connectivity from anterior to posterior PFC.
Topic Area: NEUROANATOMY