Poster Session A, Saturday, March 23, 1:30 pm - 3:30 pm, Pacific Concourse
Alpha Klotho Protein correlates with Hippocampal Volume related cognitive changes induced by aerobic exercise in older adults
Andreas Becke1,2, Anne Maass1,2, Michael Kreuz3, Emrah Düzel1,2; 1German Center for Neurodegenerative Diseases, Magdeburg, Germany, 2Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, 3Leibniz Institute for Neurobiology, Magdeburg, Germany
Aerobic exercise is an important component to delay neurodegeneration in old age. One mediating factor is the expression of neurotrophic and vascular growth factors as well as life extension factors namely Alpha-Klotho protein. A reduced level of Alpha-Klotho is related to cognitive decline, while increased values with slowing progression of Dementia, possibly induced by a down regulation hippocampal neurogenesis. Yet the relation of exercise induced Alpha-Klotho level changes on the effect of hippocampus volume and memory Performance remained unclear. Forty healthy older humans (mean age=68.4±4.3, 55% female) were pseudo-randomly assigned to either an aerobic exercise group (indoor treadmill, n=21) or to a control group. Hippocampus Volumes were gained from manual segmentations of 7Tesla-T1 images (0.6 mm isometric voxels) which were acquired along a cognitive test battery, serum fasting blood samples for analysis of human soluble Alpha-Klotho and ergospirometry measures (volume of oxygen consumption) at the beginning and the end of a 3-month aerobic exercise intervention. Mean values of individual changes of hippocampal volumes, memory scores for delayed memory recognition in complex figure task (RCF), Alpha-Klotho and oxygen consumption at ventilatory threshold were compared between groups and further used for regression analysis, corrected for age and gender. Residuals show a significant positive correlation between RCF scores and Alpha-Klotho levels as well as a positive correlation of hippocampal volume and Alpha-Klotho. These findings were irrespective of fitness changes but more prominent in the exercise training group. The results provide additional evidence for the function of Alpha-Klotho mediating adult hippocampal neurogenesis.
Topic Area: EXECUTIVE PROCESSES: Development & aging