Poster Session A, Saturday, March 23, 1:30 pm - 3:30 pm, Pacific Concourse
Socioeconomic status, minority status, and neighborhood deprivation effects on brain structure and cognitive function: A multivariate analysis of the ABCD study dataset
Carlos Cardenas-Iniguez1, Marc Berman1; 1The University of Chicago
Childhood low socioeconomic status (SES), widely associated with increased psychosocial and environmental stress, has been previously associated with differences in brain morphometry and cognitive function. The current study aims to investigate these findings further by also exploring the contribution of various social and neighborhood environmental factors on cognitive function and cortical volume. To accomplish this goal, we used Canonical Correlations Analysis (CCA), a multivariate analysis approach that allows us to find linear combinations of two sets of variables that have maximum correlation with each other, termed Latent Variables (“LVs”). For this study, we used a subset of participants from the first release of the ABCD Study for which a full set of data were available (3150 subjects, 1488 female, average age: 120 months). We implemented CCA to relate cortical volume estimates for 68 regions (34 per hemisphere) according to Freesurfer’s Desikan-Killiany atlas to measures in the following categories: demographics (race/ethnicity, age, gender, and SES), cultural and social environment, residential neighborhood conditions (using the Area Deprivation Index) and cognitive function (from the NIH Toolbox Cognitive Function Battery). Our CCA yielded two LVs, together accounting for 60% of the variance, that showed a strong positive relationship between cortical volume across all regions and better cognitive performance, and identifying as White, being male, having higher parental education and income, and having better residential neighborhood conditions, and a strong negative relationship with being Black and experiencing greater neighborhood deprivation. These results suggest a benefit to multivariate approaches on SES and cognitive function.
Topic Area: EXECUTIVE PROCESSES: Development & aging