Poster Session F, Tuesday, March 26, 8:00 – 10:00 am, Pacific Concourse
Dimensions of Psychopathology are Dissociably Linked to Brain Structure in Youth
Antonia Kaczkurkin1, Sophia Seonyeong Park2, Aristeidis Sotiras1, Tyler M. Moore1, Matthew Cieslak1, Zaixu Cui1, Daniel H. Wolf1, Daniel S. Pine3, Ruben C. Gur1,4, Christos Davatzikos1, Raquel E. Gur1, Theodore D. Satterthwaite1; 1University of Pennsylvania, 2Temple University, 3National Institute of Mental Health, 4Philadelphia Veterans Administration Medical Center
High comorbidity among psychiatric disorders suggests that they may share underlying neurobiological deficits. Abnormalities in cortical thickness and volume have been demonstrated in clinical samples of adults, but less is known about when these structural differences emerge in youth. The purpose of this study was to examine the association between dimensions of psychopathology and brain structure. We studied 1,394 youth imaged as part of the Philadelphia Neurodevelopmental Cohort. Dimensions of psychopathology were constructed using a bifactor model of symptoms. Cortical thickness and volume were quantified using high-resolution MRI at 3T. Structural covariance networks were derived using non-negative matrix factorization and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear developmental effects. Fear symptoms were associated with reduced cortical thickness in the anterior and posterior cingulate cortex, temporal-parietal junction, anterior insula, as well as orbitofrontal and temporal cortex. Overall psychopathology was associated with globally reduced gray matter volume across all networks. Lastly, structural covariance networks predicted psychopathology symptoms above and beyond demographic characteristics and cognitive performance. Our results suggest a dissociable relationship whereby fear is most strongly linked to reduced cortical thickness and overall psychopathology is most strongly linked to global reductions in gray matter volume. Such results have implications for understanding how abnormalities of brain development may be associated with divergent dimensions of psychopathology, and suggest potential biomarkers that could be used to enhance personalized interventions for psychiatric disorders in youth.
Topic Area: NEUROANATOMY