Poster Session B, Sunday, March 24, 8:00 – 10:00 am, Pacific Concourse
Studies on Measurement and Classification of Restricted and Repetitive Behaviors in Autism Spectrum Disorders
Zixuan Zhang1; 1Sparkzone Institute
Restricted and repetitive behavior (RRB) is one of the core features of autism spectrum disorder (ASD) which consists of a group of heterogeneous behaviors. This work tries to clearly describe the definition and measurement of this phenotype to provide deep insights to the psychological and pathological causes of RRBs, thereby making discussions on RRBs classification. First, tools of the measurement of RRBs mainly include direct clinical observation of children (e.g. Autism Diagnostic Observation Scale), parental development history interview (e.g. Autism Diagnostic Interview-Revised) and parental questionnaire (e.g. Repetitive Behavior Scale-Revised). Further, comparisons on different aspects (e.g. accuracy and severity) are made to reveal differences across these instruments. This work also concludes that future research on this topic should focus more on systematic analysis across instruments and aim to establish reliable biochemical biomarkers or endophenotypes behind RRBs. Second, this study elaborates on the two types, i.e., repetitive sensory motor (RSM) and insistence on sameness (IS), which correspond to lower level and higher level RRBs, respectively, of RRBs identified and mostly supported by a number of existing studies. A third factor circumstanced interest (CI) may also exist. Studies are also made to investigate on the association between the two factors, i.e., RSM and IS, and intelligence quotient (IQ) as well as chronological age. In addition, accurate classification of RRBs can provide an alternative approach to constitute homogenous samples in studies and therefore enable the detection of genomic loci related to this behavior.
Topic Area: EXECUTIVE PROCESSES: Development & aging