Poster Session F, Tuesday, March 26, 8:00 – 10:00 am, Pacific Concourse
Executive Dysfunction in Traumatic Brain Injury is Related to Chronic Symptom Status, Not Injury Severity
Keith Main1,2,3, Anna-Clare Milazzo2,3, Bernard Ng3, Salil Soman4, Jordan Nechvatal2,3, Jennifer Kong2, Stephanie Kolakowsky-Hayner5, Ansgar Furst2,3, J. Wesson Ashford2,3, Maheen Adamson1,3; 1Defense and Veterans Brain Injury Center, 2War Related Illness and Injury Study Center, 3Stanford University School of Medicine, 4Harvard University Medical School, 5Icahn School of Medicine at Mount Sinai
The chronic symptoms associated with traumatic brain injury (TBI) may be partly due to alterations in the connectivity of neural networks. Using resting-state fMRI and diffusion weighted imaging, we examined functional and structural connectivity in 57 participants: 23 with chronic TBI and 34 without. We hypothesized that chronic symptom status would correlate with altered functional connectivity in predefined regions of the dorsolateral prefrontal and lateral parietal cortices (executive control network). Regression analyses demonstrated that chronic symptoms significantly predicted decreased connectivity in the left executive control network. Additional between-group tests showed decreased connectivity for the left dorsolateral prefrontal cortex of the chronic symptom group. Further tests on 14 large-scale, resting-state networks revealed a decrease in chronic symptom connectivity between the following networks: left executive control, retrosplenial/medial temporal, and precuneus/posterior cingulate. Structural connectivity measured by fractional anisotropy correlated with initial injury severity but not chronic symptom status. Our results suggest that a decrease in functional connectivity in the left executive control network, particularly connections with the left dorsolateral prefrontal cortex, aligns more closely with chronic symptom status following TBI than injury severity.
Topic Area: EXECUTIVE PROCESSES: Other