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Molecular and Psychosocial Markers of Cognitive Resilience in a Super‐Ager Cohort: Insights from Santiago, Chile

Poster Session C - Sunday, March 8, 5:00 – 7:00 pm, Fairview/Kitsilano Ballrooms

Angela C. Sierra¹ (angelacsierra2017@gmail.com), María Paulina Correa², Moisés Sandoval González², Lindsay Kobayashi³; ¹The Graduate Center of the City University of New York, ²Institute of Nutrition and Food Technology of the University of Chile, ³University of Michigan School of Public Health

As global aging accelerates, understanding the biological and psychosocial mechanisms that sustain cognitive and physical resilience in later life has become a pressing scientific priority. This ongoing comparative study includes 40 Super-Agers and 40 age-comparable typical older adults in Santiago, Chile, defined by younger-norm MMSE performance, and preliminary data suggest meaningful cognitive variation, with controls exhibiting patterns consistent with accelerated aging. By integrating neuroscience, geroscience, public health, and clinical medicine, the study aims to explore patterns of biological aging and their interaction with psychosocial factors. Theoretical models suggest that social determinants, such as low socioeconomic status, minority status, and adverse life events, may interact with molecular hallmarks of aging. The first analytic phase evaluates associations between telomere length and DNA methylation (DNAm) age, estimated using multiple epigenetic clocks (Horvath 1, Horvath 2, Hannum, PhenoAge, GrimAge, and DNAm telomere length) to capture varied dimensions of biological aging. Remarkably, one participant’s estimated epigenetic age is 57 despite a chronological age of 86, illustrating individual differences in molecular aging trajectories. Designed analyses will compare participants at the extremes of DNAm age to identify distinguishing biological and functional features. By integrating biological and psychosocial perspectives, this study aims to refine hypotheses about potential causal pathways, inform interventions to promote healthy aging and longevity, and contribute to the broader field of aging research. We welcome feedback on study design, analytic strategies, and potential interpretations to refine ongoing work.

Topic Area: EMOTION & SOCIAL: Development & aging