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The IL-10 -872 Polymorphism Differentially Modulates the Relationship Between Serum IL-10 and Cognitive Performance in Methamphetamine Use Disorder

Poster Session F - Tuesday, March 10, 2026, 8:00 – 10:00 am PDT, Fairview/Kitsilano Ballroom

DongMei Wang^1,2 (), Yang Tian^1,2, HuiJuan Liu^1,2, XiangYang Zhang³; ¹Institute of Psychology, Chinese Academy of Sciences, ²University of Chinese Academy of Sciences, ³Tsinghua University

Growing evidence indicates that immune dysregulation contributes to neurocognitive impairment in individuals with methamphetamine use disorder (MAUD). Interleukin-10 (IL-10), an anti-inflammatory cytokine, exerts be neuroprotective and helps maintain neuronal functions; however, its relationship with cognitive deficits in MAUD remains unclear. Genetic variations, such as IL-10 -872 G/T polymorphism, may influence cytokine production. This study aimed to investigate whether this polymorphism modulate this association between IL-10 and cognitive performance in MAUD. We recruited 568 male MAUD patients from a drug rehabilitation center and 210 male healthy controls (HCs) from the local community in China. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum IL-10 levels and IL-10-872 G/T genotype were determined. Compared to HCs, MAUD patients exhibited widerspread cognitive impairment across multiple RBANS domains and had significantly elevated serum IL-10 levels. Although The IL-10 -872 G/T genotype was not associated with IL-10 levels, but it differentially influenced cognitive function between group. Among MAUD patients, TT homozygotes showed better attention domain performance compared to G-allele carriers, whereas no such genotypic difference was observed in HCs. Moreover, higher IL-10 levels negatively correlated with performance in language, delayed memory, and total cognitive score only in HCs with TT genotype. No significant correlations were detected in MAUD patients. These results suggest that the IL-10 -872 G/T polymorphism moderates the association between IL-10 and cognitive in healthy individuals, but this regulatory relationship is disrupted in MAUD, providing new insights into the role of IL-10 in substance-related cognitive dysfunction.

Topic Area: OTHER