Schedule of Events | Search Abstracts | Symposia | Invited Symposia | Poster Sessions | Data Blitz Sessions

Poster F52 - Postdoctorial Fellowship Award Winner

Age-related differences in theta oscillations across development: insights from intracranial EEG and brain structure-function relationships

Poster Session F - Tuesday, April 16, 2024, 8:00 – 10:00 am EDT, Sheraton Hall ABC

Zachariah Cross1 (, Samantha Gray1, Adam Dede1, Qin Yin2,17, Parisa Vahidi2, Elias Rau3, Christopher Cyr1, Ania Holubecki1, Eishi Asano2, Jack Lin4, Olivia Kim McManus5, Shifteh Sattar5, Ignacio Saez4,6, Fady Girgis4,7, David King-Stephens8,9, Peter Weber Weber9, Kenneth Laxer9, Stephan Schuele1, Joshua Rosenow1, Joyce Wu1,10, Sandi Lam1,10, Jeffrey Raskin1,10, Kurtis Auguste11,12, Edward Chang11, Ammar Shaikhoun13, Peter Brunner14, Jarod Roland14,, Rodrigo Braga1, Robert Knight16, Noa Ofen2,17; 1Northwestern University, 2Wayne State University, 3Ruhr University Bochum, 4University of California, Davis, 5University of California, San Diego, and Rady Children’s Hospital, 6Ichan School of Medicine at Mount Sinai, 7University of Calgary, 8California Pacific Medical Center, 9Yale University, 10Ann & Robert H. Lurie Children’s Hospital of Chicago, 11University of California, San Francisco, 12UCSF Benioff Children’s Hospital, 13Ohio State University and Nationwide Children’s Hospital, 14Washington University in St. Louis, 15St. Louis Children’s Hospital, 16University of California, Berkeley, 17University of Texas at Dallas

Neural oscillations change across the human lifespan, concurrent with changes in cognition and brain structure, emphasizing their importance in understanding brain development. Scalp-EEG is the primary tool in developmental neuroscience research. However, it cannot access memory-related brain regions, such as hippocampus. Here, we isolated slow (~1.5 – 4.5 Hz) and fast theta (~4.5 – 8 Hz) frequencies in a developmental intracranial EEG (iEEG) cohort (n = 83, n channels = 4618; Mage = 16.40 years, range = 5.93 – 54 years, 51 males). Using task-based (i.e., attending to to-be-remembered visual stimuli) and task-free recordings, we quantified age-related differences in slow and fast theta frequencies in primary sensory, limbic, and association cortices. Mixed-effects regressions revealed that in precentral gyrus, slow theta slowed with increasing age during task-free but not task-based states (p =.002), while the inverse was observed for fast theta (p =.03). In MTL, slow theta slowed with age irrespective of task state (p =.001). In dorsolateral prefrontal cortex, fast theta slowed with age irrespective of task state (p =.005). In relating structure-to-function, for both slow and fast theta in MTL, we observed significant interactions between gray matter volume and task state. Yet, despite the importance of MTL and prefrontal theta oscillations to memory, we found no significant relationship in these regions between age and theta frequencies on recognition accuracy, suggesting age-related variability in theta frequencies reflects a natural feature of development. These findings indicate that theta varies across development, differs by task state, and relates to brain structure.

Topic Area: LONG-TERM MEMORY: Development & aging


CNS Account Login


April 13–16  |  2024