Poster F65, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Sex differences in the brain during long-term item memory
Dylan S. Spets1, Scott D. Slotnick1; 1Boston College
There is little evidence on sex differences in the human brain during long-term memory. In the current study, we reanalyzed data from two fMRI experiments to investigate the similarities and differences in brain activity between males and females during long-term item memory. In both experiments, during encoding, abstract shapes were presented to the left or right of fixation. During retrieval, old and new shapes were presented at fixation and participants classified each shape as “old-left”, “old-right”, or “new”. A random-effect general linear modal analysis was conducted (N = 11 males, 11 females). To isolate item memory, we contrasted item memory hits (with incorrect spatial location responses) and item memory misses. Contrasts were thresholded at p < .001, corrected to p < .05. As expected, for both males and females, this contrast produced activity in the dorsolateral prefrontal cortex, the parietal cortex, the hippocampus, and visual processing regions. The conjunction of item memory hits versus misses for males and females produced a limited number of small activations. The contrast of item memory hits for males versus females revealed very different patterns of activity. Males showed greater activity in the middle frontal gyrus, the medial anterior prefrontal cortex, and the hippocampus. Females showed greater activity in Broca’s and Wernicke’s areas, and early and late visual regions. Males and females also showed different patterns of activity in the anterior prefrontal cortex and the parietal cortex. Our results suggest that males and females recruit largely different brain regions during long-term item memory.
Topic Area: LONG-TERM MEMORY: Episodic