Poster C19, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Personality Measures and Reward-Related Neural Activations among Individuals with Different Substance Using Patterns
Tien Tong1, Jatin Vaidya1, John Kramer1, Samuel Kuperman1, Doug Langbehn1, Daniel O’Leary1; 1University of Iowa Carver College of Medicine
Use of substances is associated with enhancement of positive affect (PA) and reduction of negative affect (NA). Individual differences in PA and NA are in turn associated with differential brain responses to reward and loss, respectively. The purpose of this study was to examine the associations between substance use and positive motivational (PA; reward activations), negative motivational (NA; loss activations), and control (impulsivity) processes. Toward this goal, we recruited 221 emerging adults (112 males, Mean Age=18.69) with varying levels of substance use (controls, monosubstance use: alcohol, and polysubstance use - PSU: alcohol and marijuana), as well as varying levels of alcohol use (Bingers – have 4-6 (females) or 5-8 (males) drinks in 2 hours, and Extreme Bingers – have 8+ (females) or 10+ (males) drinks in 2 hours). Heightened impulsivity was associated with cumulative use of both alcohol and marijuana (p’s<.05). PA and NA, however, were correlated with marijuana use (p’s<.01) but not with alcohol use. When participants were categorized into groups (Controls, Bingers, Extreme Bingers, PSU Bingers, and PSU Extreme Bingers), there was no significant group effect for PA and NA. Neural activation of monetary gain revealed similar results. Activation in the mesial prefrontal cortex during gain outcome was marginally correlated with alcohol use (p=.05) but not marijuana use, and groups with different substance use patterns didn’t show a difference in reward activation. In summary, choices of different substances as measured by cumulative use were related to PA, NA, and reward-related neural activation.
Topic Area: EMOTION & SOCIAL: Other