Poster F10, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Alterations in Intrinsic Functional Brain Connectivity for Hypertensive Women Post-Menopause
Judith Lobo1, Nicole Rotkovitz1, Julia Weinman1, Roger McIntosh1; 1University of Miami
Loss of ovarian estradiol enhances risk of neurological disease and of hypertension. Cardio vascular risk factors are linked with with cognitive deficits and altered resting-state connectivity. Menopause and aging may be interacting with this effect. The current study aims to characterize and contrast intrinsic connectivity of hypertensive (HTN) and normotensive women as a function of age-menopause. Fifty-two post-menopausal women were selected from the NKI Rockland Study (HTN aged 63.42 years ± 13.00 NTN aged 65.37 years ± 14.72), 26 hypertensive and 26 normotensive. A group probabilistic independent component analysis (PICA) was performed in FSL using the MELODIC program in order to identify functional networks. Differences in intrinsic connectivity of several resting state networks were found as a function HTN status and the interaction of HTN with menopausal age. NTN women showed more robust activity in the Executive Control Network (ECN) and Salience network. When the interaction with age was included, activity of the the Default Mode network (DMN) and the Salience network (SN) was more robust in the normotensive group. Activity of the DMN, SN, Temporal network and Dorsal Attention network was more robust in the hypertensive group.The interaction between post-menopausal age and HTN status suggests that there is a synergistic relationship between the two factors that may be contributing the accelerated aging in the brain. Due to the importance of some of the identified networks in carrying out cognitive tasks, altered brain connectivity is a possible mechanism for cognitive changes associated with hypertension and aging in post-menopausal women.
Topic Area: EMOTION & SOCIAL: Development & aging