Poster E61, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Effects of aging on functional networks in the cortical midline structures underlying the self-reference effect by taking self-perspectives
Takashi Tsukiura1, Karin Norimoto1, Rie Yamawaki1,2,3, Yayoi Shigemune1,4; 1Graduate School of Human and Environmental Studies, Kyoto University, 2Graduate School of Medicine, Kyoto University, 3Kyoto University Hospital, 4Graduate School of Letters, Chuo University
Memories for the self-related information are remembered more accurately than those for the other-related information (SRE: self-reference effect). Functional neuroimaging studies have demonstrated the importance of the cortical midline structures (CMS) including the medial prefrontal cortex (mPFC) in SRE, and this effect by knowledge-based self is relatively preserved in older adults. However, evidence is scarce in the age-dependent changes of neural mechanisms underlying SRE in event-based self manipulated by taking self-perspectives. To investigate this, we scanned 25 healthy young and 22 healthy older adults in our fMRI study. During encoding with fMRI, participants viewed event scenes by two strategies of the self- (Self) and other-perspective taking (Other). In Self, participants viewed scenes by projecting themselves onto the events, whereas a third person's view was employed as a viewing strategy in Other. During retrieval, participants made old or new judgments for scenes in high and low confidence. All encoding trials in each condition were categorized into subsequent hits (Hit) and misses (Miss). Young adults showed significantly larger SRE than older adults. In fMRI results, age-related decreasing activation in Self-Hit vs. Other-Hit was identified in the ventral and dorsal mPFC, precuneus, and hippocampus, whereas no region showed a significant aging effect in Self-Miss vs. Other-Miss. In the gPPI analysis for Self-Hit, functional connectivity of the dorsal mPFC and hippocampus with the precuneus, and of the dorsal PFC with the ventral PFC was significantly reduced by aging. Aging effects on SRE by event-based self could reflect the lower CMS network in older adults.
Topic Area: LONG-TERM MEMORY: Episodic