Poster F90, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Rhythm-based temporal prediction in children with Autism Spectrum Disorder (ASD)
Shlomit Beker1,2, John J. Foxe1,2,3, Sophie Molholm1,2,3; 1The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY., 2Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (IDDRC), Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY., 3The Ernest J. Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY
Information in the sensory environment tends to be highly predictive of upcoming events, allowing for online planning and decision-making. The neural processing of predictable stimuli is significantly facilitated compared to non-predictable stimuli. Clinical observations and behavioral tasks suggest that people with ASD have deficits in applying predictive information to generate expectations, leading to a decreased surprise when violated. In spite of this evidence, neuronal correlates of these impaired processes remain to be identified. Using electrophysiology, this study aims to define the neural activity underlying the altered prediction in ASD, through examining the role that impaired neural entrainment might play in reduced prediction of upcoming information, and the generation of the preparatory potential. We tested the integrity of temporal prediction by presenting rhythmic visual and auditory stimuli on children with ASD and age-matched typically developing (TD) controls, while recording from 64 scalp EEG channels. Participants responded to the appearance of an auditory stimulus that was either preceded by predictive rhythmic visual stimuli, or not. Both time- and frequency domains were analyzed. Results show that in contrast to TD, who present preparatory activity in temporal channels prior to the appearance of the auditory target, children with ASD present reduced preparatory activity. In addition, patterns of event-related oscillatory activity differed between the groups, as was evident prior to the predicted event, with greatly altered stimulus-driven resonant oscillations. We offer a possible explanation, based on cortical activity in reaction to rhythmic sensory stimuli, for impaired event prediction in children with ASD.
Topic Area: PERCEPTION & ACTION: Development & aging