Poster D72, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
Dopaminergic modulation of associative memory in healthy humans
Erin Kendall Braun1, Katherine Duncan2, Ragy Girgis3, Suzanne Wood2, Madeleine Sharp4, Camilla van Geen1, Anissa Abi-Dargham5, Daphna Shohamy1,6,7; 1Columbia University, 2University of Toronto, 3New York State Psychiatric Institute, 4Montreal Neurological Institute, 5Stonybrook University, 6Zuckerman Mind, Brain Behavior Institute, 7Kavli Institute for Brain Science
For memory to be adaptive, the brain must prioritize memory for events that are motivationally relevant. It has been proposed that dopamine plays an important role in prioritizing memory for these motivationally relevant events by promoting long-term potentiation in the hippocampus. However, many open questions remain about the effect of dopamine on long-term memory in healthy humans and when these effects emerge. We examined the effect of a dopamine agonist (d-amphetamine) on hippocampal-dependent associative memory in healthy human participants (n=60). Participants encoded novel pairs of objects during two different sessions: once while on either drug or placebo and once with no drug. We tested memory both immediately after encoding and after a week delay; associative memory accuracy was determined by asking participants to indicate if object pairs were intact (a pair of objects studied together), rearranged (a pair of objects studied in different combinations), or new (at least one object was new). D-amphetamine levels during encoding were related to better associative memory accuracy when memory was tested both immediately and after a delay. These results complement cellular and physiological data and show that dopamine at encoding promotes the prioritization of events in memory, with implications for understanding the role of memory in adaptive behavior.
Topic Area: LONG-TERM MEMORY: Episodic