Poster C95, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Cortico-Cerebellar Pathways for Understanding Language Coordination
Magda L. Dumitru1, Laurens Van Calster1, Marion Bouffier1, Steve Majors1; 1University of Liege
The cerebellum plays an essential role in both motor and cognitive aspects of human spatial navigation, contributes to sensorimotor integration, and directly affects thalamic and motor cortex activity. We investigated the role of cortico-cerebellar pathways in understanding brief language structures composed of two words linked by a coordinator (“gorilla and/or castor”). The volunteers were 22 right-handed adults scanned on a 3T Siemens Magnetom Prisma. We ran whole-brain univariate analyses using SPM12 (http://www.fil.ion.ucl.ac.uk/spm) and estimated brain responses at each voxel using GLM with event-related regressors. Group MVPA and functional connectivity analyses ran using the CONN Functional Connectivity SPM Toolbox (Whitfield-Gabrieli & Nieto-Castanon 2017) identified the cerebellum along with the middle temporal gyrus, the superior frontal gyrus, the paracingulate gyrus, and the lateral occipital cortex as key structures involved in understanding language coordination, suggesting that its mental representations are highly embodied and recruit sensorimotor structures routinely involved in concrete perception and action. We also explored differences in hemispheric contribution to understanding language coordination by calculating the average values of structure-function relationships for probabilistic cytoarchitectonic maps (the SPM Anatomy Toolbox - Eickhoff et al. 2005). The Laterality Index LI (Left - Right/Left + Right) was strongly negative for the “and>or” contrast and strongly positive for the “or>and” contrast in the same tasks.
Topic Area: PERCEPTION & ACTION: Motor control