Poster D91, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
Odor Familiarity and the Conversion from Mild Cognitive Impairment to Alzheimer’s
Paul Wheeler1, Claire Murphy1,2,3; 1San Diego State University, 2SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 3University of California San Diego
The current study evaluated the utility of odor familiarity, a measure of remote memory that does not require odor naming, to differentiate healthy controls from those who convert from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Odor familiarity deficits have been observed in AD however, its potential utility in signaling prodromal Alzheimer’s disease in unknown. An archival sample of 249 participants with MMSE and odor memory data from the Alzheimer’s Disease Research Center study at the University of California San Diego was used in the analysis. Two hundred twenty-two of the participants were healthy controls, and 17 converted from MCI to AD. Stimuli consisted of common household odors. Familiarity was assessed utilizing a visual analogue scale with participants being asked to rate a presented odor from “not at all familiar” to “very familiar.” The receiver operating characteristic (ROC) / area under the curve (AUC) for prediction of conversion from MCI to AD utilizing the MMSE was .65 and odor familiarity was .68. The results suggest the potential utility of odor familiarity deficits in predicting those who convert from MCI to AD. Odor familiarity could also benefit clinical trials of disease modifying drugs as they become available. Supported by NIH grant # AG004085-26 from the National Institute on Aging to CM. We thank the participants and staff of the UCSD ADRC (P50AG005131).
Topic Area: PERCEPTION & ACTION: Development & aging