Poster D49, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
Auditory fMRI language ‘localizer’ study with epilepsy patients
Beau Snoad1, Phillip Gander1, Matthew Howard III1; 1University of Iowa
Language processing is supported by an extensive network including temporal, frontal and parietal regions. In surgical epilepsy patients, the localization of these areas is critical for postsurgical outcomes. We used a new passive auditory language ‘localizer’ task (Scott et al. 2016) to identify key cortical regions supporting language in 7 surgical epilepsy patients. We collected non-simultaneous fMRI and electrocorticography (ECoG) data in each patient. The task consists of 16 pairs of degraded and non-degraded speech stimuli presented across two runs. Neural responses to non-degraded and degraded speech stimuli were contrasted to each other and to silence using SPM12. On a single subject level, we first contrasted responses to speech versus silence and found distinct activations in bilateral auditory cortex and planum temporale (p<0.05 uncorrected). When comparing degraded versus non-degraded speech we found that non-degraded stimuli elicited robust activations of primary auditory cortex and insula (p<0.05 uncorrected). In contrast, degraded stimuli activated the anterior cingulate, orbitofrontal cortex (OFC) and prefrontal cortex (PFC) (p<0.05 uncorrected). These activity patterns were similar across subjects. ECoG data is currently being analyzed for further comparisons between methods. These preliminary results identify a network of high-level language processing regions at the individual subject level and support findings from previous studies. More importantly, these findings show that the new passive auditory language ‘localizer’ is suitable for the pre-surgical evaluation of epilepsy patients.
Topic Area: LANGUAGE: Other