Poster B95, Sunday, March 25, 8:00-10:00 am, Exhibit Hall C
Exercise impacts information processing and neural activity under varying cognitive demands in children treated for brain tumours
Elizabeth Cox1,2, Sonya Bells1, Janine Piscione1, Brian W. Timmons3,4, Ute Bartels1,2, Cynthia de Medeiros1, Jovanka Skocic1, Kiran Beera1, Suzanne Laughlin1,2, Donald J. Mabbott1,2; 1Hospital for Sick Children, Toronto, Ontario, Canada, 2University of Toronto, Toronto, Ontario, Canada, 3McMaster University, Hamilton, Ontario, Canada, 4McMaster Children's Hospital, Hamilton, Ontario, Canada
Children treated with cranial radiation for brain tumours exhibit continuous declines in information processing. Critically, reduced information processing speed (IPS) impairs cognition under greater task demands and relates to aberrant brain function. Exercise improves IPS and enhances neural activity. Here we aim to assess the efficacy of exercise training (ClinicalTrials.gov: NCT0194476) to improve IPS and underlying functional mechanisms during an increasingly demanding Go/No-Go visual-motor reaction time (RT) task using Magnetoencephalography (MEG) among this population. During MEG recording participants (n=20, 12.46 ± 3.03 years) pressed a button immediately after a green cross appeared (simple condition, SC) and additionally withheld response when a red cross appeared (increased demand condition, IDC) on a screen. Data with extraneous movement and electromagnetic artifacts was removed prior to analysis and subsequently filtered into 6 frequency bands. Changes in RT and neural activity after exercise were investigated. Linear mixed-effects regression was used to assess changes RT and local neural activity. Changes in functional connectivity were evaluated using partial least squares regression. After exercise, participants demonstrated stable visual-motor RT during the SC and IDC (p>0.05). During the SC, participants exhibited decreased high gamma (60-100Hz) power in the right cuneus after viewing the green cross (p=0.02-0.05) and increased connectivity between cerebellar and cortical sensorimotor sources during the button press (p<0.01). High gamma oscillations likely facilitate efficient information transfer. Thus, these preliminary results suggest exercise mitigates declines in IPS under increasing cognitive demands and improves functional mechanisms that support visual-motor IP under minimal demand in children treated for brain tumours.
Topic Area: PERCEPTION & ACTION: Motor control