Poster F27, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Relations between catechol-O-methyltransferase (COMT) genotype and inhibitory control development in childhood
Maureen Bowers1, George Buzzell1, Virginia Salo1, Troller-Renfree Sonya1, Hodgkinson Colin2, Goldman David2, Gorodetsky Elena3, McDermott Jennifer4, Henderson Heather5, Nathan Fox1; 1University of Maryland, College Park, 2National Institute on Alcohol Abuse and Alcoholism, 3National Institute of Health, 4University of Massachusetts, Amherst, 5University of Waterloo
The Val108/158Met SNP of the catechol-O-methyltransferase (COMT) gene, primarily involved in dopamine breakdown within prefrontal cortex, has shown relations with executive functioning and inhibitory control (IC) in both adults and children. However, little is known about how COMT genotype relates to the development of inhibitory control throughout childhood. Here, we examined the effects of the MetMet genotype compared to ValVal and ValMet genotype on IC trajectories from ages 5 to 9. Children completed a Go/Nogo task at ages 5, 7, and 9; IC was characterized using signal detection theoretic measures to examine both IC performance (d’) and response strategy (criterion). COMT genotype was related to developmental trajectories in IC performance from age 5 to age 9, with MetMet chidlren exhibiting similar levels of IC performance at age 5, but more rapid development of IC performance compared to ValVal and ValMet children during childhood. COMT genotype was not related to initial response strategy in IC at age 5 or developmental changes in IC response strategy. These results show that COMT genotype modulates the development of IC performance in mid-childhood.
Topic Area: EXECUTIVE PROCESSES: Development & aging