Poster D70, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
Unique Frontal Activation Patterns Associated with Depression Severity during Memory Retrieval in Women
Jennifer Sneider1,2, Julia Cohen-Gilbert1,2, Derek A. Hamilton4, Carolyn Caine1, Maya Rieselbach1, Emily Oot1,3, Anna Seraikas1, Lisa D. Nickerson1,2, Marisa M. Silveri1,2,3; 1McLean Hospital, 2Harvard Medical School, 3Boston University School of Medicine, 4University of New Mexico
Major depressive disorder (MDD) is a debilitating disorder that interferes with normal daily functioning, and which occurs at a markedly higher rate in women relative to men. Evidence of structural and functional alterations in hippocampus and the frontal lobe also have been reported in MDD, which likely contribute to the multifaceted impact of this condition. Functional magnetic resonance imaging data were acquired at 3Tesla during a hippocampal-based spatial memory task in 15 women across a clinical spectrum of MDD, from none to current MDD. Depression severity, assessed via the Beck Depression Inventory (BDI), was examined relative to brain activation. Greater activation was observed, regardless of depression severity, in right hippocampus, bilateral fusiform, left superior-parietal lobe and occipital regions during memory retrieval relative to motor control. In contrast, there were no significant areas of activation observed for motor control relative to retrieval. Notably, despite similar behavioral performance across participants, during rest relative to retrieval, activation in superior frontal gyrus and cingulate gyrus, regions of the default mode network (DMN), was significantly associated with depression severity (BDI). The observed lateralized activation of right hippocampus during spatial navigation is consistent with previous findings reported in women. In addition, failure to suppress activity in DMN as a function of depression is consistent with a frontal lobe inefficiency that may contribute to clinical state. Linking mood, brain activation, and cognition may help to better diagnose MDD in women, as well as inform prevention and treatment efforts targeting women, thereby alleviating suffering from this debilitating condition.
Topic Area: LONG-TERM MEMORY: Episodic