Poster C1, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Comparisons of Mismatch Negativity in Clinical High Risk and Schizophrenia Populations
Ian T. Kim1, Migyung Lee1,2, Pejman Sehatpour1,2, Cheryl M. Corcoran1, Daniel C. Javitt1,2; 1Columbia University Medical Center, 2Nathan Kline Institute
Auditory mismatch negativity (MMN) is a well-characterized biomarker for schizophrenia. However, there have not been many studies investigating whether auditory MMN deficits exist in the clinical high risk (CHR; or prodromal) population. In this investigation, we tested multiple types of deviation from a standard tone, including the well-studied duration deviant and the frequency-modulated (FM) tone. The detection of the later type of mismatch is hypothesized to be related to emotion recognition, used here to investigate if prodromal MMN response is different compared to patients with schizophrenia (SCZ) and healthy controls (HC). Preliminary analysis of time-domain event-related potential (ERP) show that although the MMN waveform in CHR do not differ significantly from SCZ or HC in both duration and FM mismatch conditions, there is a modulatory effect that segregates the three groups. Furthermore, the wider standard error of the means in the duration compared to the FM condition indicate that the FM deviant produces a relatively more consistent difference. This project builds on the previous studies of MMN in SCZ and expands its applicability in CHR.
Topic Area: EMOTION & SOCIAL: Other