Poster F85, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
The mediate effect of changes in resting-state functional connectivity on resilience due to short-term intensive meditation: a randomized controlled trial
Seoyeon Kwak1, Tae Young Lee2, Wi Hoon Jung3, Ji-won Hur4, Dahye Bae1, Wu Jeong Hwang1, Kang Ik K. Cho2, Kyung-Ok Lim5, So-Yeon Kim6, Hye Yoon Park7, Jun Soo Kwon7; 1Seoul National University, Republic of Korea, 2SNU-MRC, Republic of Korea, 3Korea University, Republic of Korea, 4Chung-Ang University, Republic of Korea, 5National Institute of Forensic Psychiatry, Ministry of Justice, Republic of Korea, 6Duksung Women’s University, Republic of Korea, 7Seoul National University Hospital, Republic of Korea
In recent decades, studies have examined the beneficial effects of short-term meditation on stress resilience and related neural substrates. More recent work has explored the maintenance of these effects; however, the underlying neural mechanisms have not yet been investigated. To investigate the neural mechanisms that maintain the beneficial effects of short-term meditation on stress resilience, we conducted a randomized controlled trial of a four-day meditation practice. Thirty participants in meditation practice and 17 participants in a relaxation retreat (control group) underwent MRI scans and self-reported questionnaires [Cognitive and Affective Mindfulness Scale (CAMS) and Resilience Quotient Test (RQT)] at baseline, post-intervention, and 3-month follow-up. Both groups showed increased CAMS and RQT scores immediately after the intervention, but only meditation group maintained the enhancement after 3 months. Furthermore, the resting-state functional connectivity (rsFC) between the left rostral anterior cingulate cortex (rACC) to the dorsomedial prefrontal cortex (dmPFC), precuneus, and angular gyrus was significantly increased immediately after the intervention in meditation group compared with that in the control. Changes in the rACC-dmPFC rsFC mediated the relationship between the changes in CAMS and RQT in the meditation group, and the changes in the rACC-dmPFC rsFC were correlated with the RQT changes at both immediate and 3-month follow-up. Thus, increased rACC-dmPFC rsFC induced by short-term intensive meditation not only mediated the immediate improvement of resilience but also guaranteed its maintenance after 3 months. Thus, short-term meditation may be beneficial to individuals for the improvement of stress-related neural mechanisms, leading to behavioral improvement and its maintenance.
Topic Area: OTHER