Poster F84, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Contribution of the prefrontal and parietal regions to time estimation and temporal control: A study of patients with a brain tumor before and after surgery
Yayoi Shigemune1,2, Shoko Saito2, Kentaro Hiromitsu1,2, Kanako Hamamoto3, Nobusada Shinoura4, Ryoji Yamada4, Akira Midorikawa1,2,3; 1Graduate School of Letters, Chuo University, Tokyo, Japan, 21Institute of Cultural Science, Chuo University, Tokyo, Japan, 3Faculty of Letters, Chuo University, Tokyo, Japan, 4Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
Time estimation is defined as cognitive processing of duration over a range from seconds to minutes, and is important in terms of temporal action control. Early neuroimaging studies suggested that the prefrontal cortex (PFC) and the parietal lobe (PL) were involved in time estimation. Here, we investigated the effects of brain tumors in the PFC and PL, and surgery treating such tumors, on time estimation and behavioral control. In all, 10 patients with PFC tumors, 9 with PL tumors, and 20 healthy controls were enrolled; they did not differ significantly in terms of age, sex, or performance on a cognitive screening test. All participants underwent 1 min counting and tracing tasks. In the former task, all participants subjectively evaluated the passage of 1 min; the actual elapsed time was recorded using a stopwatch. In the tracing task, all participants traced a square with sides of 20 cm, in a clockwise direction, as slowly as possible for 2 min. Patients with PFC tumors underestimated the passage of 1 min compared to controls, and patients with either PFC or PL tumors exhibited faster tracing speeds than controls. However, the tracing speed was slower after surgery in patients with PL tumors. These results suggest that the PFC plays a critical role in time estimation and that a deficit in temporal behavioral control improves after surgery, associated with preservation of time estimation executed in the PFC.
Topic Area: OTHER