Poster F16, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Neural correlates of emotional inhibitory control in adolescents with and without family history of alcoholism
Maya Rieselbach1, Lisa D. Nickerson1,3, Jennifer T. Sneider1,3, Anna Seraikas1, Emily Oot1,4, Carolyn Caine1, Elena Stein1, Sion K. Harris2, Marisa M. Silveri1,3,4, Julia E. Cohen-Gilbert1,3; 1McLean Hospital, 2Boston Children's Hospital, 3Harvard Medical School, 4Boston University School of Medicine
Adolescence is a period characterized by elevated impulsivity, particularly in the context of intense emotions. Response inhibition deficits and difficulties regulating emotions are associated with alcohol use and other substance use disorders. Family history of alcoholism (FH) status is also associated with inhibitory control deficits, altered brain activation during inhibitory control tasks, and elevated risk for alcoholism. In this study, brain activation data were collected via functional magnetic resonance imaging (fMRI) while 30 healthy adolescents (ages 13-14, 15 female) performed an inhibitory control task (Go-NoGo) with distracting background images that were positive, negative, neutral, or scrambled. Adolescents had no personal history of substance use and were stratified into FH positive (FH+, parent and/or grandparent history of alcoholism, n=10) and FH negative (FH-, n=20) groups. A mixed model ANOVA examining NoGo trial accuracy revealed a significant interaction between trial background and FH status (p=.017). Post hoc analyses showed significantly lower NoGo accuracy on negative trials in FH+ versus FH- adolescents (p=.015), but no group differences on positive, neutral, or scrambled trials. Brain activation on inhibitory (NoGo) trials was contrasted between negative and neutral conditions. Results showed recruitment of bilateral inferior frontal gyrus (IFG) during the negative versus neutral contrast in the FH- but not the FH+ group. These findings suggest that adolescents with family history of alcoholism exhibit diminished impulse control in the context of negative emotional states, possibly due to a lack of recruitment of executive control regions, which may link to inherited risk for substance use and abuse.
Topic Area: EMOTION & SOCIAL: Emotion-cognition interactions