Poster C40, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Metabolic Syndrome and its Association with Self-Reported Sleep Quality and Cognitive Function
Tori Ferland1,2, Saba Chowdhry3, William Milberg1,2, Regina McGlinchey1,2, Elizabeth Leritz1,2; 1Harvard Medical School, 2VA Boston Healthcare System, 3Boston University School of Medicine
Inadequate sleep quality and duration have been associated with the development of cerebrovascular risk factors such as obesity, diabetes, hypertension and hyperlipidemia. Chronic sleep deprivation has also been associated with poor cognitive performance in many populations. Metabolic Syndrome (MetS) is characterized by three or more co-occurring risk factors for cerebrovascular disease and has been linked to poor sleep quality. However, less is known about the effect of sleep quality on cognitive function in this particular MetS sample. The purpose of this study was to examine how sleep quality in MetS impacts neuropsychological function. 117 adults (mean age 61.44) completed the PSQI, a well-validated, self-report questionnaire that assesses the quality and patterns of sleep over a 1-month time interval. A comprehensive battery of neuropsychological tests and measurements of blood pressure, cholesterol, weight, and fasting glucose were also obtained. Fifty-four participants were diagnosed with MetS according to NCEP-III guidelines. The two groups differed on the PSQI global sleep quality score, with the MetS group reporting significantly worse sleep quality than the control group. Within the MetS sample, poor sleep quality was significantly associated with worse performance on tests of working memory and executive function. Our results are consistent with prior literature, demonstrating that self-reported poor sleep quality is significantly related to MetS and its individual risk factors. However, to the best of our knowledge, this is the first study to demonstrate that inadequate sleep quality and duration may have a specific impact on executive function and working memory in MetS.
Topic Area: EXECUTIVE PROCESSES: Working memory