Poster A24, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
Resting-State EEG Coherence in Young Children with ADHD: A Potential Neural Marker of ADHD
Sarah Furlong1, Jessica Cohen1, Joseph Hopfinger1, Jenna Snyder1, Margaret Sheridan1; 1University of North Carolina, Chapel Hill
Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly prevalent neurodevelopmental disorder. However, evidence suggests that ADHD is over-diagnosed in community samples, under-diagnosed in females and minorities, and potentially misdiagnosed in early childhood (<8 years). Current diagnostic tools relying on parental report are not sufficient to address these issues, but neural measures have potential for improving early childhood diagnoses. It is thought that ADHD is characterized by disrupted functional brain network organization, thus that may be a potential diagnostic biomarker. It has been shown with fMRI that distinct brain networks are more segregated from other networks in children (ages 8-12) with ADHD than in typically developing (TD) children. In older children and adults, differences in theta band activity in electroencephalogram (EEG) recordings are associated with differences between individuals with ADHD and controls. Communication across brain networks and theta band power are implicated in the cognitive functions that are impaired in ADHD. In the current study, we recorded resting-state EEG in 52 unmedicated children with ADHD and 52 age- and gender-matched TD children (ages 3-7). We observed significant increases in theta band power (4-7 Hz) over central parietal electrodes in ADHD relative to TD children. Preliminary network analyses did not find group differences in the degree of segregation between distinct brain networks either within theta or across all frequency bands. However, within theta, data-driven assignment of EEG electrodes to brain networks resulted in different network assignment in key regions, including central parietal electrodes, indicating that network organization is altered in young children with ADHD.
Topic Area: EXECUTIVE PROCESSES: Development & aging