Poster D94, Monday, March 26, 8:00-10:00 am, Exhibit Hall C
The impact of a cognitive-psychophysiological therapy on motor planning and execution in Tourette syndrome patients
Simon Morand-Beaulieu1,2, Marie-Ange Perreault1,2, Kieron P. O'Connor1,2, Pierre J. Blanchet1,2, Marc E. Lavoie1,2; 1Centre de recherche de l’Institut universitaire en santé mentale de Montréal, Montreal, QC, Canada, 2Université de Montréal, Montreal, QC, Canada
In recent years, cognitive-behavioral therapies have made important progress among available treatment options for Tourette syndrome (TS). One of those therapies, the cognitive-psychophysiological (CoPs) therapy, aims at regulating the chronically heightened sensorimotor activation and elevated muscle tension in TS patients. It has been proved to effectively decrease tics, but can also improve motor skills. However, the neurobiological mechanisms underlying such changes are not fully understood. Therefore, this project aims at studying the impact of the CoPs therapy on electrocortical brain activity related to motor planning and execution in TS patients. Electroencephalogram (EEG) activity was recorded in 21 TS patients and 23 healthy controls during a Stimulus-Response Compatibility task. EEG data were processed into lateralized readiness potentials (LRP). The LRP are obtained through a double subtraction of event-related potentials, to eliminate any activity unrelated to motor processes. Both the stimulus-locked (sLRP) and response-locked (rLRP) LRP were measured. LRP onset and maximum peak were assessed before and after the therapy for the TS group. The control group was also tested twice with a similar interval between both assessments. Results showed that prior to therapy, sLRP onset was delayed in TS patients, compared to healthy controls. The CoPs therapy allowed an acceleration of the sLRP onset in TS patients. In healthy controls, the sLRP onset did not change over the 4-month interval, suggesting that the acceleration seen in TS patients is attributable to the therapy and not to repetition. Therefore, CoPs therapy appears to induce a modification of motor processes in TS patients.
Topic Area: PERCEPTION & ACTION: Motor control