Poster A33, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
Context-dependent inhibition impairments for executing familiar action task found in patients with frontal glioma
Chiharu Niki1, Takatsune Kumada2, Takashi Maruyama1, Manabu Tamura1, Yoshihiro Muragaki1; 1Tokyo Women's Medical University, 2Kyoto University
【Introduction】Patients with right frontal lobe damage who showed using unnecessary objects when performing sequential tasks were reported as action disinhibition syndrome (Niki et al., 2009). For example, objects using for “wrap a gift” and those for “calligraphy” were presented to them and they were asked to wrap a gift, they wrote a message for the gift using calligraphy. In this study, we investigated inhibitive action errors in detail. 【Methods】Patients: 16 patients with frontal glioma (11 right, 5 left). Task: Single tasks and distractor object-paired-tasks were administered. For single tasks, only objects necessary to perform the target task were presented. For distractor object-paired-tasks, in addition to necessary objects, distractor objects that were not be used normally in a target task were also presented. Patients were instructed to perform a target task. “Distractor error” that they used distractor objects were analyzed. 【Results】Distractor errors were found in 4 left and 7 right glioma patients. 3 left glioma patients showed distractor errors that were not related to the action goal of target task. On the other hand, all 7 right glioma patients showed only distractor errors that were associated to goal of target task. 【Discussion】There were two types of distractor errors, which were related or not related to goal of target task. A set of objects such as “calligraphy” would have a context that affect control for action sequence. To use only necessary object, inhibitive function for context emerged from objects might be necessary.
Topic Area: EXECUTIVE PROCESSES: Other