Poster A3, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
Default-Executive coupling in attention control after traumatic brain injury with task functional magnetic resonance imaging in longitudinal study.
Shun-Chin Wu1,2, Lei Wang1, Fan-pei Gloria Yang3, Furen Xiao4; 1Northwestern University, Chicago, IL 60611, USA, 2National Defense Medical Center, School of Medicine, Taipei, Taiwan, 3National Tsing Hua University, Hsinchu, Taiwan, 4National Taiwan University Hospital, Taipei, Taiwan
Deficits in goal-oriented executive function such as working memory are common in individuals with Traumatic Brain Injury (TBI). Recent longitudinal neuroimaging studies showed increased activation and connectivity in TBI patients. During a 5-week observation period, we examined changes in goal-oriented executive function in 21 patients with brain injury in post-acute phase, using a face/scene matching 1-back functional magnetic resonance imaging (fMRI) task (Chen, 2012). The block-design fMRI task involved two types of interleaving stimuli: relevant and irrelevant, depending on whether the current stimulus matched the goal category (face or scene). We used multivariate pattern analysis (MVPA) to assess the relevant vs. irrelevant stimuli contrast as indication of clarity for different types of information. All data were preprocessed in SPM 12 with The Decoding Toolbox for MVPA, followed by repeat-measures ANOVA to examine longitudinal change, with a cluster FWER p=.001. Results showed that task accuracy did not change significantly. Significant increases were found in the right dorsolateral prefrontal cortex (DLPFC), right putamen and bilateral premotor cortex, and decreases in the posterior cingulate cortex (PCC), precuneus and right middle temporal gyrus in averaged information map. The combined decreases in PCC and precuneus were correlated with the increases in right DLPFC (r=-0.441, p=0.043), as with right DLPFC and putamen (r=-0.526, p=0.015). These anticorrelated changes in the executive, salience and default model networks in post-acute phase TBI patients suggest neural functional recovery at five-week follow-up that may precede any performance change. Our study can provide useful information regarding appropriate timing for future neurorehabilitation management.
Topic Area: ATTENTION: Nonspatial