Poster E102, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Structural connections differ for central vs. peripheral V1
Sara Sims1, Thomas DeRamus1, Utkarsh Pandey1, Jennifer Robinson2, Kristina Visscher1; 1University of Alabama at Birmingham, 2Auburn University
Vision is an important part of our everyday life, and we use our central vision differently than our peripheral vision. For example, we use central vision to read and peripheral vision to scan a scene for danger. Different functions of central and peripheral vision suggest that information from central vision may be processed differently from that in peripheral vision. A functional connectivity study from our lab suggested that connections between centrally- and peripherally-representing visual cortex are distinct, and follow well-established networks. However, few studies have examined differential structural connections between central and peripheral representations in early visual areas. In this study, we used diffusion MRI of over 800 subjects from the Human Connectome Project. We performed probabilistic tractography on seed regions of interest in V1, corresponding to different visual eccentricities. We found that broad scale patterns of structural connectivity resembled those we had seen in functional connectivity. Regions showing stronger structural connectivity to central V1 than peripheral V1, significant after multiple comparison corrections included thalamus, superior and middle temporal gyrus, insula, and inferior and superior frontal gyrus. Regions showing the opposite effect included inferior temporal regions, lateral parietal lobe, fusiform gyrus, and middle frontal gyrus. These results suggest that eccentricity based regions are differentially structurally connected to the rest of the brain. Understanding the differential structural connections of V1 contributes to our understanding of the way the human brain processes visual information and forms a baseline for understanding any modifications in processing that might occur with training or experience.
Topic Area: PERCEPTION & ACTION: Vision