Poster A88, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
FOXP2 Variation Modulates Auditory Feedback Control of Speech Production
Siyun Zhang1, Hanjun Liu1; 1The First Affiliated Hospital, Sun Yat-sen University
Multiple lines of evidence have demonstrated the crucial role of auditory feedback in the sensorimotor integration for speech processing. Much less is known, however, about the neurobiological basis of auditory-motor control of speech production. Mutations of FOXP2 gene in humans have been found to be associated with disorders of language and speech production. In the present study, we tested the effect of a FOXP2 common variant, rs6980093 (A/G) on the vocal and event-related potential (ERP) responses to pitch feedback perturbations (-50 and -200 cents) during vocal production in a population-based cohort of 133 Chinese speakers (18-29 years old). The behavioral results showed that the GG genotype were associated with significantly smaller magnitudes of vocal compensations for pitch perturbations of -200 cents relative to the AA and AG genotypes. Furthermore, the AA and AG genotypes exhibited significant positive correlations between the magnitude of vocal compensation and the variability of normal voice fundamental frequency, while the GG genotype did not. At the cortical level, there was a significant main effect of FOXP2 genotype on the amplitudes of ERP P2 responses to pitch perturbations of -200 cents, showing significantly larger P2 amplitudes associated with the GG genotype as compared to the AA and AG genotypes. These findings show the first neurobehavioral evidence that FOXP2 variation can modulate the auditory-motor processing of pitch feedback errors during vocal production at the levels of both behavior and cortex, and provide important insights to the neural and genetic basis of speech motor control.
Topic Area: PERCEPTION & ACTION: Audition