Poster F35, Tuesday, March 27, 8:00-10:00 am, Exhibit Hall C
Functional Brain Alterations Associated with Cognitive Control in Blast-Related Mild Traumatic Brain Injury
Danielle R. Sullivan1,2, Jasmeet Hayes1,2, Ginette Lafleche1,2, David Salat2,3,4, Mieke Verfaellie1,2; 1Boston University School of Medicine, 2VA Boston Healthcare System, 3Massachusetts General Hospital, 4Harvard University
Cognitive control refers to the flexible modulation of information processing in the service of goal-directed behavior and relies on the dynamic interaction of distinct functional brain networks. Recent studies in mild traumatic brain injury (mTBI) have reported neural alterations in the absence of observable behavioral impairment in cognitive control, but no studies have examined how these alterations can be understood with reference to larger functional network dynamics. In the current study, we assessed a sample of patients with blast-related mTBI to investigate these functional networks and their role in potential behavioral and neural alterations in cognitive control. We collected event-related functional magnetic resonance imaging (fMRI) data during a flanker task in 17 individuals with blast-related mTBI and 16 individuals with blast-exposure without TBI (control). Results revealed that groups did not significantly differ in behavioral measures of cognitive control. Relative to the control group, the mTBI group showed greater deactivation of regions associated with the default mode network during the processing of errors. Additionally, error processing in the mTBI group was associated with enhanced negative coupling between the default mode network and the dorsal anterior cingulate cortex as well as the dorsolateral prefrontal cortex, regions of the salience and central executive networks that are associated with cognitive control. These results suggest that deactivation of default mode network regions and associated enhancements of connectivity with cognitive control regions may act as a compensatory mechanism for successful cognitive control task performance in mTBI.
Topic Area: EXECUTIVE PROCESSES: Other