Poster A37, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
Default mode network deactivation as a potential biomarker for working memory deficits in brain tumor patients
Irena Schouwenaars1, Miek de Dreu1, Geert-Jan Rutten, Nick Ramsey, Johan Jansma; 1ETZ Elisabeth Hospital, Department of Neurosurgery, Tilburg, the Netherlands
Introduction: Brain tumor patients often have cognitive complaints, which can greatly affect their socio-professional life. One important function that can influence cognitive performance is working memory (WM). Previous studies have shown that a high demanding cognitive task causes deactivation in a large set of brain regions: the ‘default mode network’ (DMN). In this study we examined if the level of deactivation could be associated with WM-capabilities. Materials and methods: Functional MRI scans were acquired in 46 brain tumor patients (26 meningioma, 12 low grade glioma (LGG) and 8 high grade glioma (HGG)) prior to surgery. The patients performed a 2-back task with consonant stimuli. The performance was calculated for each individual patient (number of correct responses/total amount of stimuli). Performance was correlated with DMN network activity (percentage signal change), as well as with individual regions within the DMN. Results: The level of DMN deactivation showed a trend towards significance irf correlated with performance (r = -0.23; p = 0.065). Within the DMN, we found significant correlation between level of deactivation and performance in the right angular gyrus (r = -0.37; p = 0.006) and the right posterior cingulate cortex (r = -0.28; p = 0.028). Conclusion: Our study indicates that patients with better cognitive performance show stronger deactivation within the DMN, specifically in the right hemisphere in the angular gyrus and posterior cingulate cortex. These results the possibility of using the level of deactivation in the right hemisphere as a biomarker for cognitive deficits in patients with a brain tumor.
Topic Area: EXECUTIVE PROCESSES: Working memory