Poster B24, Sunday, March 25, 8:00-10:00 am, Exhibit Hall C
Aging effects on the neural connectivity underlying the arithmetic confusion effects.
Thomas Hinault1, Kevin Larcher2, Louis Bherer3, Alain Dagher4, Susan Courtney5; 1Johns Hopkins University, 2McGill University, 3Montreal Geriatric Institute, 4McGill University, 5Johns Hopkins University
This aimed to better understand aging effects on cognitive control processes. To this end, we investigated the arithmetic confusion effect (i.e., poorer performance to correctly reject a false proposed solution when it is the correct product of another operation type; e.g., 8 + 4 = 32), previously demonstrated to involve inhibitory processes. Maintenance and updating of operation types were also studied. We analyzed DTI and fMRI data to investigate how structural and functional connectivity measures are associated with behavioral cognitive control performance and individual differences therein. Thirty-four young (18-35 years) and 34 older adults (above 65 years) performed an arithmetic verification task in a MRI scanner. Results highlighted the cognitive control network involved during the arithmetic confusion effect. Activations and connectivity (evaluated with generalized psychophysiological interactions) between ACC, IFG, DLPFC, and angular gyrus were found during confusion problems. These activations were larger when the cued operation type was previously actively maintained in working memory. With age, larger confusion effects were associated with larger frontal and posterior activations. Moreover, white matter integrity of the IFO and SLF tracts was quantified in each individual and was negatively correlated with behavioral confusion effects. This study contributes to better understand the structural and functional connectivity of cognitive control processes, together with the determinants of individual variability of cognitive control performance during aging. Results could help identify biomarkers of the level of alterations of the cognitive control connectivity in each individual.
Topic Area: EXECUTIVE PROCESSES: Development & aging