Poster B118, Sunday, March 25, 8:00-10:00 am, Exhibit Hall C
Susceptibility to boredom predicted by cortical grey matter volume in adolescents with familial risk for alcoholism
Arkadiy L. Maksimovskiy1,4, Anna Seraikas1, Emily Oot1,5, Maya Rieselbach1, Carolyn Caine1, Julia Cohen-Gilbert1,4, Jennifer T. Sneider1,4, Sion K. Harris3, Lisa Nickerson2,4, Marisa M. Silveri1,4,5; 1Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Imaging Center, McLean Hospital, Belmont, MA, 2Applied Neuroimaging Statistics Lab, McLean Imaging Center, McLean Hospital, Belmont, MA, 3Boston Children’s Hospital, Harvard Medical School, Boston, MA, 4Harvard Medical School, Boston, MA, 5Boston University School of Medicine, Boston, MA
Developmental reductions in grey matter volume (GMV) coincident with adolescence have been associated with age-related maturation of behavioral and cognitive control. Adolescents with a family history of alcoholism (FH+) exhibit alterations in grey matter structure that may confer neurobiological vulnerability for future hazardous drinking. To date, only focal regions have been examined in FH studies of brain structure. Thus, this study examined the influence of FH status on whole-brain morphology, and associations with sensation seeking and impulsiveness, two traits known to predict hazardous drinking. Thirty-three adolescents, ages 13-14 years old, were stratified into FH+ (n=17) and FH- (n=15) groups. Participants underwent magnetic resonance imaging (MRI) at 3T and completed the Brief Sensation Seeking Scale (BSSS) and the Barratt Impulsiveness Scale (BIS). Volumetric brain data were extracted using the Freesurfer pipeline and all FH comparisons were analyzed using regression models that included age and sex as covariates, which accounted for head size. FH+ status was associated with larger total GMV (p<0.03), relative to the FH- group, which appeared to be driven by larger cortical (p<0.001) rather than subcortical GMV. Although behavioral measures did not differ significantly between groups, the boredom susceptibility component of sensation-seeking was negatively correlated with larger cortical GMV (p<0.01), only in the FH+ group. The relationship between higher GMV and susceptibility for boredom in the FH+ group suggests that FH status may moderate the trajectory of grey matter sculpting that is developmentally adaptive, which may provide one possible pathway to a predisposition for risk-taking behavior.
Topic Area: EXECUTIVE PROCESSES: Development & aging