Poster E106, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
An Altered Cortico-Basal Ganglia Network Activation during Reward Anticipation in Multiple Sclerosis
Pei-Pei Liu1, Angela Spirou1, Eliane Neuteboom1, Ekaterina Dobryakova1; 1Kessler Foundation, NJ
Individuals hold beliefs about the relationship between an action and its potential outcomes and such anticipation of outcomes drives one’s behavior. Deficits in reward anticipation diminish motivations for behavior and could impair everyday functioning. The fronto-striatal network has been reported to be involved in reward processing and reward anticipation. Structural abnormalities have been observed in individuals with Multiple Sclerosis (MS), a central nervous system disease that leads to nerve damages. This study examined the neural mechanisms of reward anticipation in individuals with MS, testing whether individuals with MS show alterations in fronto-striatal network activity during reward anticipation. To assess reward anticipation, participants performed a number guessing game in which they could win and lose monetary rewards during functional magnetic resonance imaging (fMRI). Contrary to our expectations, the results showed no differences in the fronto-striatal network activities during reward anticipation between MS and healthy individuals. However, MS individuals exhibited greater activation in the right hippocampus than healthy individuals. Structural analyses revealed less volume in both caudate nucleus and hippocampus in MS than in healthy individuals. Overall, we observed structural alteration but not functional alteration in the fronto-striatal network in MS. Our results also suggest that hippocampus might play a more important role in reward anticipation in MS than it does in healthy individuals.
Topic Area: THINKING: Decision making