Poster E30, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
High-frequency alpha activity and its unsuccessful reduction in schizophrenia
Kuk-In Jang1, Jihoon Oh2, Wookyoung Jung3, Sungkean Kim4, Sang Min Lee5, Seung Huh6, Seung-Hwan Lee7, Jeong-Ho Chae8; 1The Catholic University of Korea, 2The Catholic University of Korea, 3The Catholic University of Korea, 4The Catholic University of Korea, 5The Catholic University of Korea, 6The Catholic University of Korea, 7The Catholic University of Korea, 8The Catholic University of Korea
Previous studies have demonstrated an attenuation in resting-state electroencephalography (EEG) alpha bands in schizophrenia. The alpha activity decreases during cognitive task performance compared to resting state. The change in alpha activity underlying disturbed cognitive function in schizophrenia is not well understood. Because abnormal alpha activity levels could be related to cognitive deficits, how the alpha activity is altered during task performance and in the resting state can help understand the pathophysiology of schizophrenia. This study investigated the attenuation of alpha activity in schizophrenic patients, and compared between event-related alpha activity and resting-state alpha activity. Thirty-four patients with schizophrenia and 29 healthy controls were recruited. EEG was performed in the resting state and during the auditory P300 task. The delta, theta, low-frequency alpha, high-frequency alpha , low-frequency beta, high-frequency beta, and gamma EEG bands were analyzed. In schizophrenia, the high-frequency alpha activity was reduced in the resting state. Furthermore, the high-frequency alpha source density was decreased in both the resting state and the P300 task in patients with schizophrenia compared to that in healthy participants. Healthy controls, but not patients with schizophrenia, showed a reduction in the high-frequency alpha source density during the P300 task compared to that in the resting state. The negative correlation between the high-frequency alpha source density in the resting state and the positive symptoms of schizophrenia was significant. The high-frequency alpha activity in schizophrenic patients and its unsuccessful reduction may be biological markers of cognitive impairments in schizophrenia.
Topic Area: EXECUTIVE PROCESSES: Goal maintenance & switching