Poster E48, Monday, March 26, 2:30-4:30 pm, Exhibit Hall C
Functional Connectivity of Language and Memory as a Cognitive Biomarker in Temporal Lobe Epilepsy
Elise Roger1, Cédric Pichat1, Marcela Perrone-Bertolotti1, Emilie Cousin1, Lorella Minotti2, Anne-Sophie Job2, Chrystèle Mosca2, Philippe Kahane2, Monica Baciu1; 1Univ. Grenoble Alpes, CNRS LPNC UMR 5105, F-38000 Grenoble, France, 2Univ. Grenoble Alpes, Grenoble Institute of Neuroscience & Neurology Department CHUGA, France
Drug-resistant temporal lobe epilepsy (TLE) is a severe neurological condition that causes brain injury due to the recurrence of epileptic seizures, with mostly language (L) and memory (M) impairments. Our research aims to: (i) specify the properties of functional modifications on a language and memory network (LMN), according to the hemispheric lateralization of the epileptogenic zone (LH/RH); (ii) evaluate the efficiency of the LMN reorganizations in terms of functional connectivity (FC). Using MRI (3T Philips) we performed resting state fMRI to assess FC. 17 TLE (n=8 Left TLE; n=9 Right TLE) and a group of 28 healthy subjects were included. Two types of FC analyzes have been carried out on the LMN: ROI-to-ROI (pairwise correlations) and graph theory (integration: Eglob, Enod; segregation: Eloc) with Conn toolbox (Whitfield-Gabrieli & Nieto-Castanon, 2012). Spearman correlations were then made between FC biomarkers and LM standardized performance (verbal comprehension index, auditory memory index, naming, verbal fluency). Our main results revealed that: (a) LMN FC is extensively modified in LTLE patients (temporo-frontal and bilateral), compared to RTLE (posterior-right) and healthy; (b) the type of FC modifications depend on the cognitive function (mainly segregation for language and integration for memory); (c) FC parameters correlate remarkably with cognitive scores; (d) hyperconnectivity (increased functional integration capacity) of certain brain regions is not necessarily efficient and can negatively correlate to LM performance (negative plasticity). Thus, we wish to extend the concept of connectome to “cognitome” that taking into account the behavioral consequences of the changes observed in term of connectivity.
Topic Area: LANGUAGE: Other