Poster C34, Sunday, March 25, 1:00-3:00 pm, Exhibit Hall C
Dysexecutive impairment in first-episode of Schizophrenia
Gricel Orellana1, Andrea Slachevsky1; 1Facultad de Medicina, Universidad de Chile
Background: Deficit in executive functions may be central to schizophrenia and it is present in adolescents at risk of developing the disease [ultra-high risk], in patients with a first outbreak of schizophrenia, and apparently in their first-degree relatives. Mild to moderate impairments on executive functions tests have particularly been described in patients with a first-episode of schizophrenia. In aged schizophrenic patients, a more severe cognitive impairment has been described that mainly involves executive functions. Executive dysfunction has been significantly associated with psychosocial impairment in this disease. Despite its importance, there are still few studies that analyze the disexecutive behaviors’ in FES. We compared executive functions and disexecutive behaviors’ of a group of first-episode schizophrenia [FES] patients and a group of healthy participants using the Modified Six Elements Test [MSET], the Modified Wisconsin Card Sorting Test [MWCST], the Frontal Assessment Battery [FAB], the Questionnaire which probes symptoms of Dysexecutive syndrome [DEX] and the Behavioral Dysexecutive Syndrome Inventory [BDSI]. Methods: Twenty-two FES participants took part in this study. The 22 FES patients met the clinical and DSM-IV-TR criteria for schizophrenia in the Structured Clinical Interview for DSM-IV Axis I Disorders [SCID-I]. Nineteen FES patients were paranoid, two disorganized, and one catatonic. During the evaluations of our study, FES patients were clinically stable, receiving a single atypical antipsychotic medication. Results: We found that the control group demonstrated significantly greater Executive functions efficiency than FES patients in the tests. Patient group demonstrated significantly greater disexecutive behaviours than FES patients in the questionnaires.
Topic Area: EXECUTIVE PROCESSES: Other