Poster A116, Saturday, March 24, 1:30–3:30 pm, Exhibit Hall C
Investigating the relation between cognitive performance and brain activity associated with concentration in patients with a brain tumor
Miek de Dreu1, Irena Schouwenaars1, Geert-Jan Rutten1, Nick Ramsey2, Martijn Jansma1; 1Clinical Imaging Tilburg, Department of Neurosurgery, Elisabeth-TweeStedenHospital, Tilburg, The Netherlands, 2Brain Center RudolfMagnus, Department of Neurology and Neurosurgery, UMC Utrecht, Utrecht, The Netherlands
Aim: To gain knowledge about the association between cognitive performance and neurophysiological correlates of concentration in brain tumor patients. Background: Brain tumor patients often show reduced cognitive performance and report concentration problems. We study if these complaints can be associated with abnormal activation in important brain networks using an fMRI task specifically designed to measure activation associated with concentration. Method: 32 brain tumor patients performed a cued visual attention task. Patients were asked to indicate the direction of the majority of nine arrows in a three by three layout. Each trial started with a cue indicating the presentation of a stimulus. A GLM-regression analysis was performed with a regressor for trials containing the activation related to the cue. 17 patients performed similar to previously studied healthy controls (HIGH; 86 % correct ± 10 (SD) in 1223 ms ± 141). 25 patients showed lower performance (LOW; 79 % correct ± 17 in 1584 ms ± 263). We tested for differences in the central executive network (‘CEN’), the default mode network (‘DMN’), and the visual network (‘VN’) using an independent-sample T test. Results: We found no significant differences in activation between HIGH and LOW (CEN: p = 0.94, DMN: p = 0.95, VN: p = 0.50). Conclusion: The height of activation related to concentration is not associated with the performance of the task. This study indicates that patients only have problems with the execution of the task, not with concentration. Alternatively, the concentration problems were too mild to sufficiently influence task performance.
Topic Area: ATTENTION: Nonspatial